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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2009: 8: 1: 21-27 | |||||
| SPECT 영상을 이용한 경도인지장애 환자의 유형별 국소 뇌혈류 분석 | |||||
|---|---|---|---|---|---|
| 강지혜∙천상명∙박지욱∙차재관∙김상호∙강도영*∙김재우∙박경원 | |||||
| 동아대학교 의과대학 신경과학교실, 핵의학교실* | |||||
| Analysis of Regional Cerebral Blood Flow using Brain SPECT in the Patients with Mild Cognitive Impairment According to Subtypes | |||||
| Ji Hye Kang, M.D., Sang-Myung Cheon, M.D., Ji Wook Park, M.D., Jae-Kwan Cha, M.D., Sang-Ho Kim, M.D., Do-Young Kang*, Jae Woo Kim, M.D., Kyung Won Park, M.D. | |||||
| Departments of Neurology and Nuclear Medicine*, Dong-A University College of Medicine, Busan, Korea | |||||
| Background: There are few studies in the analysis of regional cerebral blood flow (rCBF) using HMPAO SPECT in mild cognitive impairment (MCI) patients according to their subtypes. The aim of this study is to assess the specific patterns of rCBF in patients with MCI using Tc-99m HMPAO SPECT, and to compare the differences of rCBF among the subtypes of MCI. Methods: We recruited 192 MCI patients consecutively according to the Petersen’s clinical diagnostic criteria, who visited to the Dementia and Memory Clinic between January 1, 2005 and December 30, 2007. Ninety seven subjects who performed the brain MRI and Tc-99m HMPAO SPECT were included in this study. They were classified by three subtypes of MCI according to their deficits in cognitive domains; amnestic single domain MCI (aMCI-s, n=23), amnestic multi-domain MCI (aMCIm, n=58), non-amnestic MCI (naMCI, n=16). The rCBF were analysised by using statistical parameter mapping (SPM) analysis method. The SPECT data of all patients with MCI were compared with those of normal control and then the three groups of MCI were individually compared with those of control subjects. Results: SPM analysis of the SPECT image showed significant perfusion deficits on the both parahippocampal gyrus, left insula and left sub-lobar in all MCI (uncorrected p<0.01). The patients with aMCI-s showed significant hypoperfusion on the left putamen and globus pallidus (uncorrected p<0.01). The patients with aMCI-m showed significant hypoperfusion areas on the left insula, left posterior cingulate gyrus, right parahippocampal gyrus and right cuneus (uncorrected p<0.01). The patients with naMCI revealed no significant hypoperfusion areas (uncorrected p<0.01). Conclusions: Our study shows characteristic and different pattern of perfusion deficits in patients with MCI. And, the pattern of perfusion deficits in amnestic multi-domain MCI are very similar to that of early stage of Alzheimer’s disease. | |||||
| Key Words: Mild Cognitive Impairment, Tc-99m HMPAO SPECT, Regional cerebral blood flow, Statistical parametric mapping (SPM) | |||||
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