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Original Article
Dementia and Neurocognitive Disorders 2009: 8: 1: 67-73

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파킨슨병 환자에서 보행동결과 인지기능의 연관성
박희경*,†∙유종윤‡∙이숙정‡∙김성렬* 김미정*∙권미선*∙이재홍*∙이명종* 정선주*
울산대학교 의과대학 서울아산병원 신경과*
한양대학교 의과대학 한양대학병원 신경과†
울산대학교 의과대학 서울아산병원, 재활의학과‡
Freezing of Gait and Cognitive Functions in Patients with Parkinson’s Disease
Hee Kyung Park, M.D.*,†, Jong-Yoon Yoo, M.D., Ph.D.‡, Suk-Jong Lee, M.D.*,‡, Sung Reul Kim, R.N.*, Miseon Kwon, Ph.D.*, Mi Jung Kim, M.D.* Jae-Hong Lee, M.D., Ph.D.*, Myoung C. Lee, M.D.*, Sun J. Chung, M.D., Ph.D.*
Parkinson/Alzheimer Center, Department of Neurology*, Asan Medical Center, University of Ulsan College of Medicine, Seoul;
Department of Neurology†, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul;
Department of Rehabilitation‡, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Background: Freezing of gait (FOG) in Parkinson’s disease (PD) is a unique motor symptom, representing the breakdown of essential components of gait. We aimed to study the correlation between FOG and cognitive functions, particularly focusing on frontal and parietal functions, in patients with PD. Methods: We rospectively studied 25 patients with PD, including 15 PD patients with freezing (PDF) and 10 PD patients without freezing (PDNF). Gait analysis was performed with 3-dimensional gait analysis system that includes six cameras. The frequency of freezing episodes per one cycle, total step numbers per one cycle, and total time of one gait cycle were evaluated. All patients were evaluated with K-MMSE, Montreal Cognitive Assessment-Korean (MoCA-K), and Rey Complex Figure Test (RCFT). Results: In PDF, there was significant improvement in total step number, total time, gait velocity, cadence, and stride length after using visual cue. For auditory cue, in PDF, there was significant improvement in total step number, total time, freezing number, and cadence. FOG in PD was associated with some aspects of frontal dysfunction. However, there was no significant correlation between gait features and other cognitive tests, including total scores of K-MMSE, MoCA-K, and RCFT, in both PDF and PDNF. Conclusions: FOG in PD was significantly improved by external cues. FOG in PD was associated with some aspects of frontal dysfunction, which warrants for further investigations in detail.
Key Words: Freezing of gait, Parkinson’s disease, Cognitive function, Gait analysis