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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2009: 8: 2: 88-97 | |||||
| 정상인지기능을 가진 당뇨환자에서 피질하 구조의 완전성 | |||||
|---|---|---|---|---|---|
| 김희진∙문연실*,†∙한설희*,† | |||||
| 한양대학교 의과대학 신경과학교실 건국대학교 의학전문대학원 신경과학교실* 노인성질환센터† |
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| Integrity of the Subcortical Structures in Cognitively Normal Diabetics | |||||
| Hee-Jin Kim, M.D., Yeon-Sil Moon, M.D.*,†, Seol-Heui Han, M.D., Ph.D.*,† | |||||
| Department of Neurology, Hanyang University College of Medicine, Seoul; artment of Neurology*, Konkuk University College of Medicine, Seoul; Center for Geriatric Neuroscience Research, IBST†, Konkuk University, Seoul, Korea |
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| Background: It has been well known that serum glucose level is associated with cognitive dysfunction. People with type II diabetes have more hippocampal and amygdalar atrophy than non-diabetes. Besides brain atrophy, it is postulated that type II diabetes might affect the white matter structures. This leads to executive dysfunctions, which is important for every day function. The purpose of investigation was to assess the degree of subcortical white matter disruption both at structural and functional levels in diabetics without any subjective cognitive complaints. Methods: Twenty one patients with type II diabetes (mean age 65.0±6.6 yr, mean duration 4.0±2.6 yr) and 21 healthy control subjects without any subjective cognitive complaints (mean age 65.0±6.8) participated in this study. We employed diffusion tensor imaging analysis for the assessment of structural integrity of subcortical white matter. We adopted the Executive Interview (EXIT 25) to assess executive functional status. Results: Diabetics showed a tendency to have higher EXIT25 score compared to control group. However, white matter disruption was observed in the areas of left frontal, left deep temporal and bilateral occipital subcortices in diabetics (each Fractional Anisotrophy; FA value, 0.37±0.07, 0.39±0.06, 0.38±0.05, 0.34±0.08). Conclusions: These results showed diabetes affected the integrity of white matter in the area of anterior part of the brain, and this might associated with dysfunction of frontal executive function. | |||||
| Key Words: Diabetes mellitus, EXIT25, White matter, Diffusion tensor image | |||||
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