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Case Report
Dementia and Neurocognitive Disorders 2010: 9: 2: 69-73

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고령의 MELAS 환자에서 발생한 반복적인 뇌졸중 양 증상
Pamela Song, M.D., Jee Hoon Roh, M.D., Hyun Jin Noh, M.D., Sang Won Seo, M.D., Kwang-Ki Kim, M.D.*, Duk L. Na, M.D.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul;
Department of Neurology*, Dongguk University International Hospital, Dongguk University College of Medicine, Goyang, Korea
Recurrent Stroke-Like Episodes in a Patient with Elderly Onset Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke-Like Episodes (MELAS)
Pamela Song, M.D., Jee Hoon Roh, M.D., Hyun Jin Noh, M.D., Sang Won Seo, M.D., Kwang-Ki Kim, M.D.*, Duk L. Na, M.D.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul;
Department of Neurology*, Dongguk University International Hospital, Dongguk University College of Medicine, Goyang, Korea
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) uncommonly develops after the age of 40. We describe a patient with MELAS whose first strokelike episode presented at age 65, followed by two more episodes. The brain MR imaging for each stroke-like episode demonstrated hyperintense lesion in diffusion weighted image (DWI),and variable signal intensities in apparent diffusion coefficient (ADC) maps in temporo-parietal and occipital regions. We diagnosed the patient as MELAS with 3243A>G point mutation.
Key Words: MELAS, Elderly, Stroke, MR imaging