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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2010: 9: 3: 88-92 | |||||
| 알츠하이머병 환자의 말초혈액 내 CD34 양성세포 수치의 변화 | |||||
|---|---|---|---|---|---|
| 이순태·주 건·정근화·심지영·오민정·박명희*·김만호 | |||||
| 서울대학교병원 신경과, 진단검사의학과* | |||||
| Analysis of Circulating CD34-positive Cells in Alzheimer’s Disease | |||||
| Soon-Tae Lee, M.D., Kon Chu, M.D., Keun-Hwa Jung, M.D.,Ji-Young Sim, B.S., Min-Jeong Oh, B.S., Myoung Hee Park, M.D.*, Manho Kim, M.D. | |||||
| Departments of Neurology and Laboratory Medicine*, Seoul National University Hospital, Seoul, Korea | |||||
| Background: Circulating CD34-positive cells constitute the endothelial progenitor cell population, differentiate into endothelial cells, and contribute to mammalian brain regeneration. Given the vascular endothelial pathogenesis of Alzheimer’s disease (AD), we investigated the levels of CD34+ cells in AD patients. Methods: Sixty-six consecutive patients with probable AD (clinical dementia rating scale 1) and 22 age-matched control subjects were enrolled. CD34+ cells were counted in their peripheral blood samples and analyzed in comparison with their clinical characteristics. Results: The AD patients had significantly lower numbers of CD34-positive cells than control subjects. However, the number of CD34-positive cells was not correlated with clinical characteristics of AD patients, including Mini Mental State Examination (MMSE) score, Framingham risk score, body-mass index, and changes in MMSE during 3 months. Conclusions: AD patients have diminished circulating CD34-positive cells, suggesting the reduced regenerative support from the peripheral blood in AD patients. | |||||
| Key Words: Alzheimer’s disease, CD34, Endothelial progenitor cells, Biomarker, Mini-mental state examination | |||||
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