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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2002: 1: 2: 101-106 | |||||
| 알쯔하이머병 환자의 뇌혈류 장애 -Statistical Parametric Mapping을 이용한 Tc-99m ECD SPECT 분석- | |||||
|---|---|---|---|---|---|
| 양동원, 김범생, 손영민, 박정욱, 정용안*, 손형선*, 김상윤† | |||||
| 가톨릭대학교 의과대학 신경과학교실, 핵의학교실*, 서울대학교 의과대학 신경과학교실† | |||||
| Dysfunction of Cerebral Blood Flow in Patients with Alzheimer's Disease -Statistical Parametric Mapping analysis of Tc-99m ECD SPECT- | |||||
| Dong-Won Yang, M.D., Beum-Saeng Kim, M.D., Young-Min Shon, M.D., Jeong-Wook Park, Yong-An Chung, M.D.*, Hyung-Sun Sohn, M.D.*, Sang-Yun Kim, M.D.† | |||||
| Departments of Neurology, Nuclear Medicine*, The Catholic University of Korea College of Medicine, Seoul; Department of Neurology, Seoul National University College of Medicine†, Seoul, Korea | |||||
| Background and Objectives : Alzheimer's disease (AD) is the most common cause of the dementia. Pathologic and functional changes of AD are known to be unevenly distributed in the brain. This study investigates changes of cerebral blood flow (CBF) in patients with AD to determine brain regions with hypoperfusion that reflects progression of disease. Methods : Tc-99m-ECD single photon emission computed tomography (SPECT) was performed to measure regional CBF and statistical parametric mapping (SPM) 99 soft ware was used for the automated and objective approach to analyze SPECT image data. Twenty-five patients with mild to moderate dementia who met NINCDS-ADRDA criteria for AD (male 11, female 14) and 17 age-matched normal control subjects were studied. The severity of AD was measured by clinical dementia rating (CDR) scale. Results : SPM analysis of SPECT images revealed that CBF in the anterior cingulate gyrus, left superior parietal cortex, left medial frontal cortex, left inferior temporal cortex, right thalamus and left hippocampus was significantly decreased in AD patients compared with normal controls (corrected p<0.05). The reduction of CBF according to CDR was localized in the left hippocampus and inferior temporal cortex, right anterior and posterior cingulate cortex and right superior parietal cortex (uncorrected p<0.01). Conclusions: Our data suggest that the cognitive dysfunction of AD is strongly related with functional abnormality in discrete brain areas. 99m-Tc ECD SPECT with SPM analysis could be used as a useful functional imaging tool in AD study. | |||||
| Key Words: Alzheimer's disease, Dementia, SPECT, Statistical parametric mapping | |||||
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