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| Case Report | |||||
| Dementia and Neurocognitive Disorders 2002: 1: 2: 138-142 | |||||
| 알쯔하이머병 환자에서 Capgras 증후군 3예 | |||||
|---|---|---|---|---|---|
| 강수진, 정 용, 진주희, 윤수진*, 나덕렬 | |||||
| 성균관대학교 의과대학 삼성서울병원 신경과, 마산삼성병원 신경과* | |||||
| Three Cases of Capgras’Syndrome in Patients with Alzheimer's Disease | |||||
| Sue J. Kang, M.S., Yong Jeong, M.D., Juhee Chin, M.A., Soo Jin Yoon, M.D.*, Duk L. Na, M.D. | |||||
| Department of Neurology, Samsung Medical Center, and Masan Samsung Hospital*, Sungkyunkwan University School of Medicine, Seoul, Korea | |||||
| Capgras' syndrome, one form of the delusional misidentification syndromes, is the delusional belief in the existence of 'doubles' or 'impostors' of significant people in a patient's life. Capgras' syndrome has been considered to be associated with psychiatric disorders other than dementia. However, many recent studies have reported that this syndrome emerges frequently during the course of organic diseases such as Alzheimer's disease. Despite numerous reports about Capgras' syndrome, there have been only two case reports in Korea, in which Capgras' syndrome was caused by non-Alzheimer’s disease. We described detailed history of three patients with Capgras’syndrome associated with Alzheimer's disease. These three patients were in the early stage of Alzheimer's disease (CDR 1 or CDR 0.5) when they showed Capgras' syndrome. Target people for the delusional misbelief in all three patients were the spouses who were believed as 'a thief' or 'a stranger' in case 1; 'a stranger' in case 2; 'a mother or a father' in case 3. Two of the three patients also had negative emotion toward their husbands. Capgras' syndrome in our cases was accompanied by other behavior disturbances that included delusion of 'one's house not being one's home', paranoid delusion, and aggressiveness. In case 1, Capgras' syndrome disappeared spontaneously one year later. In contrast, in case 2 and 3, Capgras' syndrome persisted for three years and two years respectively, despite treatment with olanzapine. Our detailed description of the patients' symptoms and their caregivers' response verbatim would help Korean clinicians to manage the patients with Capgras' syndrome and to educate their caregivers. | |||||
| Key Words: Capgras' syndrome, Alzheimer's disease | |||||
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