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Original Article
Dementia and Neurocognitive Disorders 2016: 15: 4: 147-152

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Longitudinal Cerebral Perfusion Changes in Parkinson’s Disease with Subjective Cognitive Impairment
Hyeonseok S. Jeong1, Eunyoung Oh2, Jong-Sik Park3, Yong-An Chung1, Shinwon Park4, YoungSoon Yang5, In-Uk Song3
Departments of 1Radiology and 3Neurology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon, Korea 2Department of Nursing, U1 University, Yeongdong, Korea 4Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea 5Department of Neurology, Veterans Hospital, Seoul Medical Center, Seoul, Korea
Longitudinal Cerebral Perfusion Changes in Parkinson’s Disease with Subjective Cognitive Impairment
Hyeonseok S. Jeong1, Eunyoung Oh2, Jong-Sik Park3, Yong-An Chung1, Shinwon Park4, YoungSoon Yang5, In-Uk Song3
Departments of 1Radiology and 3Neurology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon, Korea 2Department of Nursing, U1 University, Yeongdong, Korea 4Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea 5Department of Neurology, Veterans Hospital, Seoul Medical Center, Seoul, Korea
Background and Purpose Although subjective cognitive impairment (SCI) is often accompanied by Parkinson’s disease (PD) and may predict
the development of mild cognitive impairment or dementia, longitudinal brain perfusion changes in PD patients with SCI remain to be elucidated.
The current prospective study examined cerebral perfusion changes in PD patients with SCI using technetium-99m hexamethylpropylene
amine oxime single photon emission computed tomography (SPECT).
Methods Among 53 PD patients at baseline, 30 patients were classified into the PD with SCI group and 23 patients were assigned to the PD
without SCI group. The mean follow-up interval was 2.3±0.9 years. The Mini-Mental State Examination, Clinical Dementia Rating, and Global
Deterioration Scale were used to assess impairments in cognitive function. Brain SPECT images were acquired at baseline and follow-up.
Results Significant differences between the two groups were not found for demographic variables, PD severity, or cognitive function at either
baseline or follow-up. At baseline, the PD with SCI group showed decreased perfusion in the left angular gyrus compared to the PD without SCI
group. Longitudinal analysis revealed widespread perfusion reductions primarily in the bilateral temporo-parieto-occipital areas and cerebellum
in the PD with SCI group. Relative to the PD without SCI group, an excessive decrease of perfusion was found in the left middle frontal gyrus of
the PD with SCI patients.
Conclusions Our findings suggest that perfusion deficits in the middle frontal area may play an important role in the pathophysiology of
SCI in PD.
Key Words: Parkinson’s disease, subjective cognitive impairment, single photon emission computed tomography, regional cerebral blood flow, cerebral perfusion.
대한치매학회지 (Dementia and Neurocognitive Disorders)