Original Article | |||||
Dementia and Neurocognitive Disorders 2016: 15: 4: 147-152 | |||||
Longitudinal Cerebral Perfusion Changes in Parkinson’s Disease with Subjective Cognitive Impairment | |||||
---|---|---|---|---|---|
Hyeonseok S. Jeong1, Eunyoung Oh2, Jong-Sik Park3, Yong-An Chung1, Shinwon Park4, YoungSoon Yang5, In-Uk Song3 | |||||
Departments of 1Radiology and 3Neurology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon, Korea 2Department of Nursing, U1 University, Yeongdong, Korea 4Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea 5Department of Neurology, Veterans Hospital, Seoul Medical Center, Seoul, Korea | |||||
Longitudinal Cerebral Perfusion Changes in Parkinson’s Disease with Subjective Cognitive Impairment | |||||
Hyeonseok S. Jeong1, Eunyoung Oh2, Jong-Sik Park3, Yong-An Chung1, Shinwon Park4, YoungSoon Yang5, In-Uk Song3 | |||||
Departments of 1Radiology and 3Neurology, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon, Korea 2Department of Nursing, U1 University, Yeongdong, Korea 4Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Korea 5Department of Neurology, Veterans Hospital, Seoul Medical Center, Seoul, Korea | |||||
Background and Purpose Although subjective cognitive impairment (SCI) is often accompanied by Parkinson’s disease (PD) and may predict the development of mild cognitive impairment or dementia, longitudinal brain perfusion changes in PD patients with SCI remain to be elucidated. The current prospective study examined cerebral perfusion changes in PD patients with SCI using technetium-99m hexamethylpropylene amine oxime single photon emission computed tomography (SPECT). Methods Among 53 PD patients at baseline, 30 patients were classified into the PD with SCI group and 23 patients were assigned to the PD without SCI group. The mean follow-up interval was 2.3±0.9 years. The Mini-Mental State Examination, Clinical Dementia Rating, and Global Deterioration Scale were used to assess impairments in cognitive function. Brain SPECT images were acquired at baseline and follow-up. Results Significant differences between the two groups were not found for demographic variables, PD severity, or cognitive function at either baseline or follow-up. At baseline, the PD with SCI group showed decreased perfusion in the left angular gyrus compared to the PD without SCI group. Longitudinal analysis revealed widespread perfusion reductions primarily in the bilateral temporo-parieto-occipital areas and cerebellum in the PD with SCI group. Relative to the PD without SCI group, an excessive decrease of perfusion was found in the left middle frontal gyrus of the PD with SCI patients. Conclusions Our findings suggest that perfusion deficits in the middle frontal area may play an important role in the pathophysiology of SCI in PD. |
|||||
Key Words: Parkinson’s disease, subjective cognitive impairment, single photon emission computed tomography, regional cerebral blood flow, cerebral perfusion. | |||||
대한치매학회지 (Dementia and Neurocognitive Disorders) |