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Case Report
Dementia and Neurocognitive Disorders 2018: 17: 1: 32-36

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Hydrocephalus in a Patient with Alzheimer's Disease
Min Ju Kang,1 Young Ho Park,1 SangYun Kim ,1 SangHak Yi 2
1Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea 2Department of Neurology, Wonkwang University School of Medicine, Iksan, Korea
Hydrocephalus in a Patient with Alzheimer's Disease
Min Ju Kang,1 Young Ho Park,1 SangYun Kim ,1 SangHak Yi 2
1Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea 2Department of Neurology, Wonkwang University School of Medicine, Iksan, Korea
Background: Normal pressure hydrocephalus (NPH) is an etiology of dementia that is
reversible following cerebrospinal fluid shunt placement, however, surgical intervention
not always clinically effective and the respons to shunt therapy is poorly understood.
Furthermore, NPH is a source of comorbidity in diseases with neurodegenerative pathology,
such as Alzheimer's disease (AD).
Case Report: A 61-year-old woman presented to the neurology clinic with progressive gait
difficulties and cognitive impairment over five years. Nine years after ventriculoperitoneal
(VP) shunt treatment, the patient began to experience frequent falls. There was no
improvement in clinical symptoms after the alteration of valve pressure on the VP shunt.
An 18F-florbetaben amyloid positron emission tomography scan showed increased diffusion
uptake over the bilateral cortices, precuneus, and posterior cingulate cortex.
Conclusions: The patient of NPH was unresponsive to shunt therapy due to the development
of AD.
Key Words: Hydrocephalus; Alzheimer Disease; Amyloid
대한치매학회지 (Dementia and Neurocognitive Disorders)