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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2014: 13: 1: 7-15 | |||||
| 알츠하이머병 환자의 단어 정의하기 능력에 관한 연구 | |||||
|---|---|---|---|---|---|
| 임성희*, 권미선†, 심현섭‡, 김상윤§, 이준영† | |||||
| 고려대학교 안암병원 재활의학과*, 울산대학교 의과대학 서울아산병원 신경과†, 이화여자대학교 언어병리학과‡, 서울대학교 의과대학 신경과학교실 & 분당서울대학교병원 신경과§, 서울대학교 의과대학 정신과학교실 & 서울대학교병원 운영 서울특별시보라매병원 정신건강의학과|| | |||||
| Word Definition Ability in Patients with Alzheimer’s disease | |||||
| Sunghee Lim, M.A.*, Miseon Kwon, Ph.D.†, Hyun-Sub Sim, Ph.D.‡, SangYun Kim, M.D.§, Jun-Young Lee, M.D.|| | |||||
| Department of Physical Medicine and Rehabilitation*, Korea University Anam Hospital, Seoul; Department of Neurology†, Asan Medical Center, University of Ulsan College of Medicine, Seoul; Department of Communication Disorders‡, Ewha Womans University, Seoul; Department of Neurology§, Seoul National University College of Medicine & Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam; Department of Psychiatry and Behavioral Science||, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea | |||||
| Background: The purposes of this study were (1) to investigate the abilities of word definition in patients with Alzheimer’s disease (AD) according to the severity, and (2) to examine the error patterns in patients with Alzheimer’s disease. Methods: Eight individuals with MCI (CDR=0.5) and 16 patients with AD (eight for probable AD mild group of CDR=1 and eight for probable AD moderate group of CDR=2) participated in the study. Eight normal age-, gender-, and education-matched elderly adults served as a control group for the MCI and AD groups. As stimuli for the word definition, eleven semantic categories were used, and two concrete words were selected from each category, resulting in a total of 22 items. Prior to the task, four definition categories were provided: 1) functional, 2) relational, 3) perceptual, and 4) categorical. Statistical analyses were performed using Kruskal-Wallis test, and Bonferroni analyses were used as a post-hoc comparison for any significant results. Results: There were significant differences in word definition scores among four groups. The probable AD moderate group showed the lower definition score than the probable AD mild group. And the probable AD moderate group showed the lower definition score than MCI group. Each group defined words in different ways. While the control group employed four definition different categories equally, the probable AD moderate group used a functional definition category mainly. However, relational and categorical definition categories were rarely observed in the probable AD moderate group. The analysis of error pattern showed that inadequate definition was frequently observed in all groups. Conclusions: The results from this study suggest that word definition task could be a sensitive indicator of the impairment of semantic knowledge in patients with AD. | |||||
| Key Words: Word definition abilities, Alzheimer’s disease, Mild cognitive impairment | |||||
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