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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2014: 13: 2: 42-45 | |||||
| 초기 알츠하이머병 환자의 호모시스테인 수준과 기억력의 관계 | |||||
|---|---|---|---|---|---|
| 박종식*·송인욱*·정성우* 강연욱†·양영순‡ | |||||
| 가톨릭대학교 인천성모병원 신경과*, 한림대학교 심리학과·한림대학교성심병원 신경과†, 보훈공단 중앙보훈병원‡ | |||||
| The Relationships between Homocysteine Levels and Memory in Early Alzheimer’s Disease Patients | |||||
| Jong-Sik Park, M.A.*, In-Uk Song, M.D.*, Sung-Woo Chung, M.D.*, Yeonwook Kang, Ph.D.†, YoungSoon Yang, M.D.‡ | |||||
| Department of Neurology*, Incheon St. Mary’s Hospital, The Catholic University of Korea, Incheon; Department of Psychology†, Hallym University, Department of Neurology, Hallym University Sacred Heart Hospital, Anyang; Department of Neurology‡, Veterans Hospital, Seoul Medical Center, Seoul, Korea | |||||
| Background: Alzheimer’s disease (AD) is a representative neurodegenerative disorder associated with memory disturbance. Recent research has shown that risk factors for cerebrovascular disorders are also causes of dementia. Of these risk factors, hyperhomocysteinemia is well known to be positively correlated with all types of dementias including AD. But it is not clear if there is a difference in the concentration of homocysteine according to subtypes of memory impairment of AD. We performed this study to explore the relationship between homocysteine and memory. Methods: A total of 54 patients (male: 15 patients) to the dementia clinic at our hospital were recruited for this study. All subjects underwent neuropsychological tests including detailed memory function tests and brain magnetic resonance images. The plasma homocysteine level was measured routinely in all patients. Results: Verbal and visual memories in AD ware significantly associated with the concentration of plasma homocysteine. The plasma homocysteine level was significantly correlated with delayed recalls of verbal and visual memories and recognition of visual memory. However, there was no relationship between plasma homocysteine and working memory. Conclusions: This study showed that plasma homocysteine level was related to the consolidation and retrieval stage of memory in AD. Therefore, we cautiously assumed that control of plasma homocysteine level could contribute to management for the prevention of cognitive impairment. | |||||
| Key Words: Alzheimer’s disease, Memory, Homocysteine | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
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