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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2003: 2: 1: 29-35 | |||||
| 의미치매에서의 PET 소견: SPM 분석 | |||||
|---|---|---|---|---|---|
| 권재철*, 강건욱†, 정지향‡, 이병화, 정 용, 조상수§, 김상은§, 나덕렬 | |||||
| 성균관대학교 의과대학 삼성서울병원 신경과, 핵의학과§, 창원 파티마 병원 신경과*, 국립 암 센터 핵의학과†, 이화여자 대학교 목동 병원 신경과‡ | |||||
| FDG-PET Findings of Semantic Dementia: an Statistical Parametric Mapping Analysis | |||||
| Kwon JC*, M.D., Kang KW†, M.D., Jeong JH‡, M.D., Lee BH, M.D., Jeong Y, M.D., Cho SS§, M.D., Kim SE§, M.D., Na DL, M.D. | |||||
| Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; *Department of Neurology, Changwon Fatima Hospital, Changwon; †Department of Nuclear Medicine, National Cancer Center, Gyeonggi; ‡Department of Neurology, Ewha Womans University Hospital, Seoul; §Department of Nuclear Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea | |||||
| Background : Semantic dementia (SD) is a temporal variant of frontotemporal lobar degeneration (FTLD), which is characterized by naming difficulty, decreased comprehension of words, prosopagnosia and object visual agnosia. We report FDG-PET findings of 6 patients with SD that was analyzed by Statistical Parametric Mapping (SPM). Methods : Six patients fulfilled the diagnostic criteria of SD proposed by consensus on FTLD diagnostic criteria. Brain MRI showed asymmetric temporal atrophies, mainly left antero-inferior temporal cortices in all patients. We performed FDG-PET scan in these patients and 11 normal controls and conducted an SPM analysis to identify brain regions with glucose hypometabolism in SD patients Results : Visually, FDG-PET images of the six patients showed hypometabolism in bilateral anterior temporal lobes, more severe on the left. Hypometablic brain regions analyzed by SPM method were left fusiform gyrus, middle, inferior temporal gyri and right superior temporal gyrus. Conclusion : Our results suggest that SD is a degenerative dementia that primarily affects anterior and basal temporal area especially of the left hemisphere. | |||||
| Key Words: Semantic dementia, Frontotemporal lobar degeneration, MRI, FDG-PET, SPM | |||||
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