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| Review | |||||
| Dementia and Neurocognitive Disorders 2017: 16: 2: 40-47 | |||||
| Subjective Cognitive Decline and Alzheimers Disease Spectrum Disorder | |||||
|---|---|---|---|---|---|
| Yun Jeong Hong,1 Jae-Hong Lee2 | |||||
| 1Department of Neurology, Dong-A University College of Medicine, Busan, Korea 2Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea | |||||
| Subjective Cognitive Decline and Alzheimers Disease Spectrum Disorder | |||||
| Yun Jeong Hong,1 Jae-Hong Lee2 | |||||
| 1Department of Neurology, Dong-A University College of Medicine, Busan, Korea 2Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea | |||||
| Subjective cognitive decline (SCD) represents subjective complaints about cognitive decline in the absence of objective impairment in neuropsychological tests. Recently, growing evidence has suggested that SCD might be the first symptomatic stage of Alzheimer’s disease (AD) pectrum disorders. However, SCD is a heterogeneous condition mixed with AD and non-AD related conditions. Hence, refinement of evidence from previous reports and standardization of the concept about SCD are needed to define appropriate target population with AD pathology. In this article, we review previous studies involving subjects with SCD, the new proposed research criteria, and characteristics of SCD in the aspect of preclinical AD. Biomarker status of SCD is also addressed. Future researches on SCD require a longitudinal follow-up with sufficient biomarker studies and proper outcome measures. | |||||
| Key Words: subjective cognitive decline, Alzheimers disease, biomarker, preclinical stage. | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) | |||||
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