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Genetics of Alzheimer's Disease
Review
Dementia and Neurocognitive Disorders 2018: 17: 4: 131-136	전문보기
Jong Hun Kim
Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, Korea
Genetics of Alzheimer's Disease
Jong Hun Kim
Department of Neurology, National Health Insurance Service Ilsan Hospital, Goyang, Korea
Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP, PSEN1, PSEN2, ABCA7, and SORL1. Genome-wide association studies have found risk genes such as ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-HLA-DRB1, INPP5D, MEF2C, MS4A6A/MS4A4E, NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1. ABCA7, SORL1, TREM2, and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.
Key Words: Alzheimer's Disease; Genetics; CRISPR-Cas Systems; Single-Cell Analysis
대한치매학회지 (Dementia and Neurocognitive Disorders)