Skip Navigation
Skip to contents

대한치매학회

검색

대한치매학회 검색

일반인 공간

학회지

권호별 검색

  • HOME
  • 학회지
  • 학회지
  • 권호별 검색
Original Article
Dementia and Neurocognitive Disorders 2024: 23: 1: 22-29

전문보기
Relationship Between Amyloid Positivity and Sleep Characteristics in the Elderly With Subjective Cognitive Decline
Kyung Joon Jo , 1 SeongHee Ho , 2 Yun Jeong Hong , 3 Jee Hyang Jeong , 4 SangYun Kim,5,6 Min Jeong Wang , 7 Seong Hye Choi , 8 SeungHyun Han,9 Dong Won Yang , 2 Kee Hyung Park 1
1 Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea 2 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 3 Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea 4 Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University School of Medicine, Seoul, Korea 5 Department of Neurology, Seoul National University College of Medicine, Seoul, Korea 6 Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Korea 7 ROA Neurology Clinic, Seongnam, Korea 8 Department of Neurology, Inha University, School of Medicine, Incheon, Korea 9 ROWAN Inc., Seoul, Korea
Relationship Between Amyloid Positivity and Sleep Characteristics in the Elderly With Subjective Cognitive Decline
Kyung Joon Jo , 1 SeongHee Ho , 2 Yun Jeong Hong , 3 Jee Hyang Jeong , 4 SangYun Kim,5,6 Min Jeong Wang , 7 Seong Hye Choi , 8 SeungHyun Han,9 Dong Won Yang , 2 Kee Hyung Park 1
1 Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea 2 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 3 Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea 4 Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University School of Medicine, Seoul, Korea 5 Department of Neurology, Seoul National University College of Medicine, Seoul, Korea 6 Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Korea 7 ROA Neurology Clinic, Seongnam, Korea 8 Department of Neurology, Inha University, School of Medicine, Incheon, Korea 9 ROWAN Inc., Seoul, Korea
Background and Purpose: Alzheimer’s disease (AD) is a neurodegenerative disease
characterized by a progressive decline in cognition and performance of daily activities. Recent
studies have attempted to establish the relationship between AD and sleep. It is believed that
patients with AD pathology show altered sleep characteristics years before clinical symptoms
appear. This study evaluated the differences in sleep characteristics between cognitively
asymptomatic patients with and without some amyloid burden.
Methods: Sleep characteristics of 76 subjects aged 60 years or older who were diagnosed
with subjective cognitive decline (SCD) but not mild cognitive impairment (MCI) or AD were
measured using Fitbit® Alta HR, a wristwatch-shaped wearable device. Amyloid deposition
was evaluated using brain amyloid plaque load (BAPL) and global standardized uptake value
ratio (SUVR) from fluorine-18 florbetaben positron emission tomography. Each component
of measured sleep characteristics was analyzed for statistically significant differences
between the amyloid-positive group and the amyloid-negative group.
Results: Of the 76 subjects included in this study, 49 (64.5%) were female. The average age
of the subjects was 70.72±6.09 years when the study started. 15 subjects were classified as
amyloid-positive based on BAPL. The average global SUVR was 1.598±0.263 in the amyloidpositive group and 1.187±0.100 in the amyloid-negative group. Time spent in slow-wave sleep
(SWS) was significantly lower in the amyloid-positive group (39.4±13.1 minutes) than in the
amyloid-negative group (49.5±13.1 minutes) (p=0.009).
Conclusions: This study showed that SWS is different between the elderly SCD population with
and without amyloid positivity. How SWS affects AD pathology requires further research.
Key Words: Alzheimer Disease; Cognitive Decline; Sleep, Slow-Wave
대한치매학회지 (Dementia and Neurocognitive Disorders)

목록

더보기

Sponsor
  • 대웅제약
  • 에자이
  • 종근당
  • 명인제약
  • 유한양행
  • 룬드백
  • 제일
  • SK케미컬
  • 한독
  • 알보젠

더보기 닫기

  • 대웅제약
  • 에자이
  • 종근당
  • 명인제약
  • 유한양행
  • 룬드백
  • SK케미컬
  • 한독
  • 셀트리온
  • 로완
서울특별시 서초구 서초중앙로 18 (서초동, 서초쌍용플래티넘) 619호
  • Tel : +82-2-587-7462
  • Fax : +82-2-587-7482
  • e-mail : secretkda@thedementia.co.kr
  • 사업자등록번호 : 214-82-63838
  • 상호 : 대한치매학회
  • 대표자명 : 최성혜 이사장

Copyright © The Korean Dementia Association, All rights reserved